In vitro evaluation of nanosecond electroporation against Trichophyton rubrum with or without antifungal drugs and terpenes

Novickij, Vitalij; Švedienė, Jurgita; Paškevičius, Algimantas; Novickij, Jurij

doi:10.1016/j.myc.2017.03.002

Use this URL to cite this publication: https://hdl.handle.net/20.500.14911/113830

In vitro evaluation of nanosecond electroporation against Trichophyton rubrum with or without antifungal drugs and terpenes

Details

Publication Type (CRIS)

Straipsnis Web of Science ir Scopus duomenų bazėje / Article in Web of Science and Scopus database (S1)

Publication Type (eLABa)

Straipsnis Web of Science DB / Web of Science DB article (S1)

VILNIUS TECH Research Priorities and Topics

Elektros ir elektroniniai įrenginiai bei sistemos / Electrical and electronic devices and systems (MC02)

Lithuanian Intelligent Specialization

Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies (L105)

Author(s)

Author	Affiliation
Novickij, Vitalij	Stiprių magnetinių laukų institutas / Institute of High Magnetic Fields (0555)
Švedienė, Jurgita	Valstybinis mokslinių tyrimų institutas Gamtos tyrimų centras
Paškevičius, Algimantas	Valstybinis mokslinių tyrimų institutas Gamtos tyrimų centras
Novickij, Jurij	Stiprių magnetinių laukų institutas / Institute of High Magnetic Fields (0555)

Title

In vitro evaluation of nanosecond electroporation against Trichophyton rubrum with or without antifungal drugs and terpenes

[en]

Vitalij Novickij, Jurgita Švedienė, Algimantas Paškevičius, Jurij Novickij

Is part of

Mycoscience

Published In

Year	Volume	Issue	Start Page	End Page
2017	58	4	261	266

Publisher

Amsterdam : Elsevier

Publisher (trusted)

Elsevier

Referenced in Database(s)(DBs)

Science Citation Index Expanded (Web of Science)

Extent

p. 261-266

URI

URI	Access Rights
https://hdl.handle.net/20.500.14911/113830
Straipsnis	Viso teksto dokumentas (atviroji prieiga) / Full Text Document (Open Access)

DOI

10.1016/j.myc.2017.03.002

Cited references

Science / Art Area

Gamtos mokslai / Natural Sciences (N)

Field of Science / Art

Biofizika / Biophysics (N011)

Biologija / Biology (N010)

Elektros ir elektronikos inžinerija / Electrical and electronic engineering (T001)

Keywords (en)

Abstract (en)

Increasing antimicrobial resistance among dermatophytes signals a need for development of new alternative therapeutic approaches for control of fungi. In this work, we analyse the antifungal activity of terpenes (linalool and y-terpene) and nanosecond electroporation. Square wave 100, 500 ns and 1 ms pulses have been evaluated in the study. Combinatorial treatments with antifungal drugs (terbinafine and itraconazole) and microsecond range (100 ms) electroporation were applied as references. We have determined that pulsed electric fields up to 30 kVcm 1 could be successfully used to inactivate T. rubrum both alone and in combination with antifungals. The applied nanosecond protocols reduced the survival of fungi up to 70%, while microsecond range protocols completely inactivated fungal colonies.