VILNIUS TECH University Research Management System (CRIS)
Use this URL to cite this publication: https://hdl.handle.net/20.500.14911/121029

Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

Publication Type (CRIS)
Straipsnis Web of Science ir Scopus duomenų bazėje / Article in Web of Science and Scopus database (S1)
Publication Type (eLABa)
Straipsnis Web of Science DB / Web of Science DB article (S1)
VILNIUS TECH Research Priorities and Topics
Biokatalitinių procesų modeliavimas / Modelling of biocatalytic processes (FM01)
Lithuanian Intelligent Specialization
Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies (L105)
Author(s)
AuthorAffiliation
Gonos, Efstathios S.
Institute of Biology, Medicinal Chemistry and Biotechnology, Athens
Kapetanou, Marianna
Institute of Biology, Medicinal Chemistry and Biotechnology, Athens
University of Athens
Sereikaitė, Jolanta  
Molekulinės biotechnologijos laboratorija / Laboratory of Molecular Biotechnology (103205)  
Bartosz, Grzegorz
University of Lodz
Naparło, Katarzyna
University of Rzeszow
Grzesik, Michalina
University of Rzeszow
Sadowska-Bartosz, Izabela
University of Rzeszow
Title
Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging
[en]
Efstathios S. Gonos, Marianna Kapetanou, Jolanta Sereikaitė, Grzegorz Bartosz, Katarzyna Naparło, Michalina Grzesik, Izabela Sadowska-Bartosz
Is part of
Aging
Published In
YearVolumeIssueStart PageEnd Page
2018
10
5
868
901
Publisher
New York : Impact Journals LLC
Publisher (trusted)
Impact Journals LLC
Referenced in Database(s)(DBs)
PubMed Central  
SCOPUS  
Current Contents / Clinical Medicine  
BIOSIS Previews  
Science Citation Index Expanded (Web of Science)  
Extent
p. 868-901
URI
URIAccess Rights
https://hdl.handle.net/20.500.14911/121029
Straipsnis
Viso teksto dokumentas (atviroji prieiga) / Full Text Document (Open Access)
DOI
Cited references
264
Science / Art Area
Gamtos mokslai / Natural Sciences (N)
Field of Science / Art
Biochemija / Biochemistry (N004)
Keywords (en)
Abstract (en)

Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.

Resource Type (COAR)
TextJournalJournal articleResearch article
Language
Anglų / English (en)
Country
Jungtinės Amerikos Valstijos / United States of America (US)
Description

This study was performed within the project "Nanomolecular antioxidants: biological basis of targeted therapy of neurodegenerative diseases" (number 2016/22/E/NZ7/00641) financed by National Science Centre (NCN), Poland in a programme "SONATA-BIS 6". The paper is also a result of realization of research projects OPUS 9 (number 2015/17/B/NZ3/03731) financed by the NCN, Poland.
This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ISSN (of the container)
1945-4589
WOS
000433605000007
Scopus
2-s2.0-85047864129
eLABa ID
29661043
Project(s)
National Science Centre (NCN), Poland
NCN, Poland